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The organ primarily responsible for purifying the blood in the human body is the kidney.

The kidneys are a pair of bean-shaped organs located on either side of the spine, just below the ribcage. Their main function is to filter waste products and excess substances, such as toxins, metabolic waste, and excess water and electrolytes, from the blood to form urine. The purified blood is then returned to circulation.

The process of blood purification in the kidneys involves millions of tiny filtering units called nephrons. Each nephron consists of a glomerulus, a tiny blood vessel cluster, and a tubule. The glomerulus filters the blood, allowing waste products, electrolytes, and water to pass into the tubule, while larger molecules like proteins and blood cells are retained in the bloodstream. Subsequently, the tubules reabsorb essential substances, such as glucose and certain electrolytes, back into the blood while directing waste products and excess substances towards the bladder as urine.

The purification of blood by the kidneys is crucial for maintaining the body's internal balance, regulating blood pressure, and ensuring proper functioning of various body systems. Kidneys also play a role in maintaining acid-base balance and producing hormones that are essential for red blood cell production and bone health.

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