When someone tells you, "hope you and your family are well," a polite and appropriate response would be to thank them and reciprocate the sentiment. Here's an example of how you could respond:
Example Response: "Thank you for your kind words! We're doing well, and I hope the same for you and your family too."
By acknowledging their well-wishes and returning the sentiment, you show appreciation for their concern and extend goodwill back to them and their family. This type of response helps maintain positive and friendly communication with the person.