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I am not a medical professional, and my knowledge is based on information available . Therefore, it's essential to consult with a qualified healthcare provider for the most up-to-date and personalized advice regarding medications for severe dissociation or Depersonalization/Derealization (DPDR) disorder.

Treatment for severe dissociation or DPDR typically involves a combination of therapy and medication. The choice of medication can vary depending on individual symptoms, medical history, and other factors. Here are some medications that have been used in the treatment of DPDR:

  1. Selective Serotonin Reuptake Inhibitors (SSRIs): SSRIs are commonly prescribed antidepressants that may help reduce anxiety and depressive symptoms associated with DPDR. They may have some effect on dissociative symptoms in some individuals.

  2. Lamotrigine: As you mentioned, lamotrigine is an anticonvulsant medication that has shown promise in reducing dissociative symptoms for some individuals, especially in cases where dissociation occurs as part of a mood disorder.

  3. Naltrexone: This medication is an opioid receptor antagonist and has been studied for its potential benefits in reducing dissociative symptoms.

  4. Atypical Antipsychotics: In some cases, atypical antipsychotic medications may be prescribed to address dissociative symptoms, especially when they co-occur with psychotic symptoms or other conditions.

Regarding benzodiazepines like Ativan (lorazepam), their use in treating dissociation or DPDR is controversial. While they can provide short-term relief from anxiety and stress, they are generally not considered a primary treatment for dissociation because they might have the potential to worsen symptoms or lead to dependence if used long-term. Benzodiazepines should be used cautiously and for short periods, if at all, under the guidance of a medical professional.

It's important to emphasize that everyone responds differently to medications, and what works for one individual may not work for another. Additionally, some medications may have side effects, interactions with other medications, or may not be suitable for certain medical conditions. Therefore, it's crucial to work closely with a psychiatrist or other mental health professional who can properly assess your condition and recommend the most appropriate treatment plan for you.

Therapies such as Cognitive-Behavioral Therapy (CBT), Dialectical Behavior Therapy (DBT), and Eye Movement Desensitization and Reprocessing (EMDR) have also shown effectiveness in helping individuals cope with dissociation and DPDR symptoms.

Always consult with a qualified healthcare provider to discuss your symptoms, medical history, and treatment options tailored to your specific needs.

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