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The difficulty of overcoming an addiction and staying clean without relapsing can vary significantly from person to person, and it depends on various factors such as the individual's biology, psychology, social support, and the specific substance being used. Different substances can have different levels of addictiveness and withdrawal symptoms, making the process of recovery more challenging for some than others.

That being said, opioids, such as heroin and prescription painkillers, are often considered among the most difficult substances to overcome due to their intense physical and psychological dependence. Opioids can create significant changes in the brain's chemistry, leading to intense cravings and severe withdrawal symptoms when attempting to quit.

Other substances that are notoriously challenging to overcome include methamphetamine, crack cocaine, and alcohol. Each of these substances can lead to profound physiological and psychological dependence, making it incredibly difficult for individuals to maintain sobriety without professional help and support.

It's essential to remember that addiction is a complex medical condition, and seeking professional treatment and support is crucial for successfully overcoming addiction and reducing the risk of relapse. There are various treatment options available, including counseling, behavioral therapies, support groups, and inpatient or outpatient rehab programs, which can significantly increase an individual's chances of achieving long-term recovery.

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