The phrase "Can you set me up with a friend?" is a request often used in the context of dating or matchmaking. When someone says this, they are asking if the person they are speaking to can introduce them to one of their friends with the intention of potentially starting a romantic relationship.
In other words, the person is expressing their interest in meeting someone new and is seeking assistance from the other person to facilitate an introduction. This could be because they trust the judgment of the person they are asking and believe that their friend might be a good match for them.
If someone asks you this question, they are essentially asking if you can play the role of a matchmaker and connect them with someone you know who might be interested in dating them. It's a way for people to expand their social circle and potentially find a romantic partner through connections and mutual acquaintances.