Seroquel, also known by its generic name quetiapine, is an antipsychotic medication used to treat various psychiatric conditions, including schizophrenia, bipolar disorder, and major depressive disorder. The drug affects several neurotransmitter systems in the brain, primarily targeting serotonin and dopamine receptors.
The two main reasons why Seroquel can cause increased hunger and tiredness are:
Histamine receptor blockade: Seroquel has strong antihistamine properties, which can lead to drowsiness and sedation. Histamine is a neurotransmitter involved in wakefulness, and when it is blocked by Seroquel, it can result in increased feelings of tiredness and fatigue.
Dopamine and serotonin modulation: Seroquel also affects dopamine and serotonin receptors in the brain. Dopamine plays a role in the brain's reward and pleasure pathways, while serotonin is involved in mood regulation and appetite control. By blocking specific dopamine and serotonin receptors, Seroquel can disrupt the body's natural hunger and satiety signals, leading to an increase in appetite.
As a result of these effects, some people may experience intense hunger and an increased desire to eat, leading to potential weight gain. Additionally, the sedative effects of Seroquel can contribute to drowsiness and fatigue, making people feel more tired than usual.
It is important to note that not everyone will experience these side effects, and the degree of their occurrence can vary from person to person. If you are prescribed Seroquel and find that these side effects are bothersome, it's essential to discuss your concerns with your healthcare provider. They may adjust the dosage, suggest lifestyle changes, or consider alternative medications to better suit your individual needs. Never stop or modify your medication without consulting your healthcare provider first, as abrupt changes can have adverse effects on your condition.