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Paracetamol suppositories primarily have a systemic effect. When a paracetamol suppository is inserted into the rectum (also known as a rectal suppository), the medication is absorbed through the rectal mucosa and enters the bloodstream. From there, it circulates throughout the body, providing pain relief and reducing fever systemically.

The rectal route is an alternative way of administering medications when oral intake is not possible, such as in cases where a patient may be unable to swallow or keep oral medications down. While rectal administration allows the drug to bypass the digestive system, it still enters the systemic circulation, allowing the active ingredient (paracetamol in this case) to have its effects throughout the body.

Paracetamol (also known as acetaminophen) is commonly used to relieve mild to moderate pain and reduce fever. The choice between oral and rectal administration may depend on individual circumstances, such as a patient's condition, age, and ability to take oral medications. As with any medication, it is essential to use paracetamol suppositories as directed by a healthcare professional to ensure safe and effective use. If you have any questions or concerns about medication administration, it's best to consult your healthcare provider or pharmacist.

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