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Yes, cyproheptadine can cause weight gain as one of its side effects. Cyproheptadine is an antihistamine that is sometimes used off-label to stimulate appetite and promote weight gain in certain medical conditions. This side effect of weight gain is often utilized in cases where increased appetite and weight gain are desired, such as in people with poor appetite due to various medical conditions, including:

  1. Cachexia: A condition characterized by severe weight loss and muscle wasting, often seen in cancer patients and those with advanced illnesses.
  2. Anorexia nervosa: An eating disorder where individuals have a distorted body image and avoid eating, leading to significant weight loss.
  3. Other appetite-related conditions: Conditions or treatments that may cause reduced appetite or weight loss.

While cyproheptadine can be helpful in promoting weight gain in these specific situations, it is essential to use it under the guidance and supervision of a qualified healthcare professional. Like any medication, cyproheptadine can have other side effects as well, and its use should be monitored to ensure its benefits outweigh any potential risks. If you are considering using cyproheptadine for weight gain, consult with your healthcare provider to discuss the appropriateness and safety of this approach for your specific situation.

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