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Combining Tylenol PM and NyQuil is generally not recommended without consulting a healthcare professional first. Both Tylenol PM and NyQuil contain active ingredients that may overlap, and taking them together could lead to an overdose of certain components, especially acetaminophen.

Tylenol PM contains acetaminophen (also known as paracetamol) and diphenhydramine, which is an antihistamine with sedative effects to help with sleep. NyQuil is a combination cold and flu medication that often includes ingredients like acetaminophen, antihistamines, dextromethorphan (a cough suppressant), and sometimes a decongestant.

Taking both medications together could potentially lead to exceeding the recommended dose of acetaminophen, which can be harmful to the liver. Acetaminophen overdose can cause serious health issues, including liver damage or failure.

Moreover, combining antihistamines from multiple medications can increase the risk of side effects such as drowsiness, dizziness, and impaired coordination.

If you are experiencing symptoms that require both Tylenol PM and NyQuil, it is essential to consult a healthcare professional, such as a doctor or pharmacist, who can evaluate your condition and recommend the appropriate medications and dosages for your specific needs.

Always read and follow the instructions and warnings on medication labels, and never hesitate to seek medical advice if you are unsure about drug interactions or potential risks.

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