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It's essential to consult with a healthcare professional or pharmacist before combining any medications, as they can provide personalized advice based on your specific health conditions and medical history.

Tylenol PM and NyQuil both contain active ingredients that can cause drowsiness. Tylenol PM typically contains acetaminophen (Tylenol) and diphenhydramine (an antihistamine). NyQuil usually contains a combination of acetaminophen, dextromethorphan (a cough suppressant), and doxylamine succinate (an antihistamine). Combining these medications can result in an excessive amount of these active ingredients and may lead to harmful effects, such as increased drowsiness, confusion, difficulty breathing, or other adverse reactions.

Using both Tylenol PM and NyQuil together can also lead to an overdose of acetaminophen, which can be dangerous for your liver. Acetaminophen is found in both medications, and exceeding the recommended dose can cause liver damage or failure.

If you have cold symptoms and trouble sleeping, it's best to choose one medication that addresses both issues or consult your healthcare provider to find a suitable solution for your specific needs. They can recommend alternatives or advise on the appropriate dosages and timing to avoid any potential interactions or adverse effects.

Always read the labels and follow the instructions on over-the-counter medications. When in doubt or if you have any concerns, it's crucial to seek professional medical advice to ensure your safety and well-being.

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