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It's essential to emphasize that discontinuing antidepressant medication "cold turkey" is generally not recommended, as it can lead to severe withdrawal symptoms, including the brain zaps, mood changes, and sleep disturbances that you are experiencing. It's crucial to work closely with a healthcare professional when changing or discontinuing medications to ensure a safe and smooth transition.

The withdrawal symptoms from duloxetine can last anywhere from a few days to several weeks or longer. The severity and duration of symptoms can vary, and some people may experience more prolonged and challenging withdrawals. Symptoms like brain zaps, mood changes, and sleepiness can be particularly uncomfortable and disruptive.

Switching to bupropion (Wellbutrin) under the guidance of your doctor can be a valid treatment approach. Bupropion works differently from duloxetine, and while it can help with depression, it might not provide immediate relief from withdrawal symptoms. It's important to give your body time to adjust to the new medication, and your doctor can monitor your progress and make adjustments as needed.

If you are experiencing severe withdrawal symptoms or if they persist for an extended period, it's crucial to reach out to your healthcare provider immediately. They can provide you with guidance on managing the symptoms, adjusting the medication regimen if necessary, or exploring other treatment options.

Remember that I am not a substitute for professional medical advice, and it's essential to consult your doctor or a qualified healthcare professional for personalized guidance on your specific situation. They can provide you with the most appropriate and safe management of your medication and overall health.

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