Dysphoria is considered a low mood. It refers to a state of unease, dissatisfaction, or emotional discomfort. Dysphoria is the opposite of euphoria, which is characterized by feelings of intense happiness and well-being. In a clinical context, dysphoria is often associated with mental health conditions such as depression and anxiety. People experiencing dysphoria may feel sad, hopeless, restless, or experience a general sense of emotional distress.