Finasteride is a medication commonly used to treat benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern baldness). It works by inhibiting the conversion of testosterone to its active form, dihydrotestosterone (DHT). While finasteride is generally well-tolerated, it can have an impact on prostate-specific antigen (PSA) levels, which are commonly measured as part of prostate health assessments.
Here are the key effects of finasteride on PSA levels:
Decreased PSA levels: Finasteride use can lead to a reduction in PSA levels by approximately 50% or more. This decline is primarily due to the fact that finasteride reduces the size of the prostate gland over time. As PSA is produced by the prostate, a smaller gland results in lower PSA production.
Impact on PSA baseline: If you start taking finasteride, it's essential to establish a new baseline PSA level after several months of consistent use. This new baseline will be lower than your previous PSA level before starting the medication.
Masking effect on prostate cancer: While finasteride lowers PSA levels, it can also mask the presence of prostate cancer by making it more difficult to detect a rise in PSA. If you're taking finasteride and are concerned about prostate cancer, your healthcare provider may need to adjust the interpretation of your PSA test results to account for the medication's effect.
Adjustments for PSA screening: When considering PSA testing for prostate cancer in individuals taking finasteride, doctors often multiply the PSA result by a factor of 2 to approximate the level it would be without the medication. This adjusted value can be more useful for monitoring changes in PSA over time.
It's crucial to communicate with your healthcare provider about any medications you are taking, including finasteride, to ensure proper interpretation of PSA test results and to monitor your prostate health effectively. Regular follow-ups and open discussions with your doctor will help you make informed decisions about your prostate health and any necessary further investigations.